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IC‐P‐060: REVEALING WHITE MATTER ABNORMALITY BY DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING BEFORE THE ONSET OF DEMENTIA IN ALZHEIMER DISEASE
Author(s) -
Wang Qing,
Blazey Tyler,
JosephMathurin Nelly,
Morris John Carl,
Benzinger Tammie
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.065
Subject(s) - splenium , fractional anisotropy , white matter , diffusion mri , dementia , corpus callosum , cingulum (brain) , pittsburgh compound b , medicine , clinical dementia rating , alzheimer's disease , psychology , magnetic resonance imaging , pathology , nuclear medicine , disease , radiology
Figure 1. Participants were divided into four groups: CDR 0, CDR 0.5, CDR 1 and CDR 2. Hippocampus volumes were significantly lower in groups with CDR 0.5, CDR 1 and CDR 2 than with CDR 0 (A, *, p<0.0005). There was no significant difference between groups with CDR 0.5, CDR 1 and CDR 2. Lateral ventricle volume in the CDR 0.5 group was significantly higher than that in the CDR 0 group (B, *, p1⁄40.0005). Lateral ventricle volume in the CDR 2 group was significantly higher than that in CDR 1 group (*, p1⁄40.0058)