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IC‐P‐039: EARLY REMODELING OF BRAIN METABOLIC ARCHITECTURE IN A TRANSGENIC RAT MODEL OF ALZHEIMER'S DISEASE
Author(s) -
Zimmer Eduardo Rigon,
Parent Maxime,
Carbonnell Felix,
Leuzy Antoine,
Shin Monica,
Kang Min Su,
Aliaga Antonio,
Wang Seqian,
Mathotaarachchi Sulantha Sanjeewa,
Schirrmacher Esher Susanne,
Soucy JeanPaul,
Gauthier Serge,
Cuello Claudio,
RosaNeto Pedro
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.043
Subject(s) - context (archaeology) , genetically modified mouse , striatum , standardized uptake value , hippocampus , medicine , positron emission tomography , neuroscience , thalamus , putamen , cortex (anatomy) , cerebellum , pathology , endocrinology , biology , transgene , dopamine , biochemistry , paleontology , gene
Conclusions: [18 F]NAV4694 (K D 1⁄42.4nM) has a wider dynamic range than [11 C]PIB (K D 1⁄44.5nM) possibly due to high affinity. Additionally, ratio between CER and WM was significantly higher for [18 F]NAV4694, which suggests lower non-specific binding than [11 C]PiB. The competition study showed that [18 F]NAV4694 cannot be fully displaced by [11 C]PIB in the HIP, which suggests binding in early forms of amyloid. Finally, these robust in vitro properties support the unique binding properties of [18 F] NAV4694 and highlight the potential of [18 F]NAV4694 for early diagnosis in AD.