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IC‐P‐016: AMYLOID PLAQUES DETECTION BY MRI: COMPARISON OF FIVE MOUSE MODELS OF AMYLOIDOSIS
Author(s) -
Vandesquille Matthias,
Po Chrystelle,
Santin Mathieu,
Herbert Kelly,
Comoy Emmanuel,
Dhenain Marc
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.020
Subject(s) - in vivo , ex vivo , pathology , magnetic resonance imaging , amyloid (mycology) , amyloidosis , gadolinium , medicine , chemistry , biology , radiology , microbiology and biotechnology , organic chemistry
incubation with VHH-DOTA/Gd showed numerous hypointense spots in the cortex (Figure 2A). Moreover, several hypointense spots were colocalised (red arrows) with amyloid plaques revealed by the reference technique of Gd-staining (Figure 2B). Conclusions: This study demonstrates that VHHs cross the BBB, label amyloid plaques in vivo and can be detected by MRI following conjugation with a contrast agent. VHHs thus appear as promising tools with translational value for in vivo detection of amyloid deposits.