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At the interface of sensory and motor dysfunctions and Alzheimer's disease
Author(s) -
Albers Mark W.,
Gilmore Grover C.,
Kaye Jeffrey,
Murphy Claire,
Wingfield Arthur,
Bennett David A.,
Boxer Adam L.,
Buchman Aron S.,
Cruickshanks Karen J.,
Devanand Davangere P.,
Duffy Charles J.,
Gall Christine M.,
Gates George A.,
Granholm AnnCharlotte,
Hensch Takao,
Holtzer Roee,
Hyman Bradley T.,
Lin Frank R.,
McKee Ann C.,
Morris John C.,
Petersen Ronald C.,
Silbert Lisa C.,
Struble Robert G.,
Trojanowski John Q.,
Verghese Joe,
Wilson Donald A.,
Xu Shunbin,
Zhang Li I.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.514
Subject(s) - sensory system , neuroscience , disease , psychology , cognition , motor system , dementia , motor function , physical medicine and rehabilitation , medicine , pathology
Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age‐related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled “Sensory and Motor Dysfunctions in Aging and AD.” The scientific sessions of the workshop focused on age‐related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory‐motor deficits in AD may enhance patient function as AD progresses.