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O5‐03‐06: ALZHEIMER'S DISEASE INCIDENCE DECLINED IN AFRICAN AMERICANS, BUT NOT IN YORUBA
Author(s) -
Gao Sujuan,
Ogunniyi Adesola,
Hall Kathleen Steele,
Baiyewu Olesegun,
Unverzagt Frederick,
Lane Kathleen A.,
Gureje Oye,
Hake Ann,
Hendrie Hugh
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.493
Subject(s) - dementia , medicine , cohort , incidence (geometry) , gerontology , population , demography , cohort study , prospective cohort study , yoruba , pediatrics , disease , environmental health , linguistics , philosophy , physics , sociology , optics
DSM-III-R after sequential screening with the Mini Mental State Examination (MMSE) and Cambridge Examination for Mental Disorders in the Elderly (CAMDEX). Cox proportional hazards models were used to estimate hazard ratios. For more robust effect-estimates, we meta-analyzed the hazard ratios from the 0-4, 4-8, and 8-12 year intervals from both analyses, based on the Martingale properties of Cox regression. Results: In the cohort followed from baseline, 814 persons developed dementia, while in the cohort followed from repeated coffee assessment, 578 persons developed dementia. Analysis of entire follow-up showed no association between coffee and dementia. However, a congruent pattern of risks was observed in the 4-year intervals. After both coffee-assessments, we found a protective association between coffee and dementia in first 4 years, which reversed in the later intervals; highest risk being in the 8-12 year interval. We highlight that the 0-4 year interval after repeated assessment corresponds to the 8-12 year interval in the cohort followed from baseline. Meta-analysis of hazard ratios in 0-4 year interval from the two follow-ups showed a statistically significant protective association between coffee-intake and dementia (HR 0.79, 95% CI: 0.60, 0.97). Similarly, meta-analysis of hazard ratios from 8-12 year interval yielded a significant result (HR 1.26, 95% CI:1.03, 1.53). Conclusions: Our data suggest that the protective association observed in the short-term is a selection by health; coffee-intake like other lifestyle factors is a proxy of health and general well-being of participants.