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O5‐02‐01: PREVALENCE, TOPOGRAPHY, AND RISK FACTORS OF CEREBRAL MICROBLEEDS IN DEMENTIA
Author(s) -
Shams Sara,
Martola Juha,
Granberg Tobias,
Li Xiaozhen,
Shams Mana,
Fereshtehnejad Mohammad,
Cavallin Lena,
Aspelin Peter,
Wiberg Maria Kristoffersen,
Wahlund LarsOlof
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.482
Subject(s) - dementia , medicine , cerebral amyloid angiopathy , memory clinic , hyperlipidemia , odds ratio , diabetes mellitus , angiopathy , vascular dementia , cognitive decline , disease , cardiology , endocrinology
used to define differences between CBF of theWMH layers and NAWM.Results: The CBF in the surrounding regions of WMHs was significantly lower than the NAWM CBF at layers 1 through 11 (L1-L11) in PV WMH, and at layers 1 through 10 (L1-L10) in deep WMH. In both PV and deep WMH, CBF gradually increased from the inner to outer layers. In comparison to the deepWMHCBF, PVWMHCBF (core and edge) was significantly lower. Conclusions: Lower CBF in the surrounding area of WMH may identify a penumbra, or tissue that is at risk for developing into a lesion. Lower CBF exists approximately 1 cm around WMHs for both PVand deep lesions, which could be used as a target area for treatment and prevention trials. The lower CBF in the PV WMH compared to deep WMH suggests that the underlying evolution process of the WMH in these two locations might be different.