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O5‐01‐05: COMPARING ATROPHY PATTERNS IN EARLY CLINICAL STAGES ACROSS DISTINCT PHENOTYPES OF ALZHEIMER'S DISEASE
Author(s) -
Lehmann Manja,
CohnSheehy Brendan I.,
Pijnenburg Yolande,
Seeley William,
Berckel Bart,
Miller Bruce,
Lehmann Manja,
GornoTempini MariaLuisa,
Kramer Joel H.,
Flier Wiesje M.,
Rosen Howard,
Scheltens Philip,
Jagust William,
Barkhof Frederik,
Rabinovici Gil Dan
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.480
Subject(s) - clinical dementia rating , early onset alzheimer's disease , atrophy , temporal lobe , primary progressive aphasia , voxel based morphometry , dementia , posterior cortical atrophy , psychology , voxel , neuroscience , precuneus , alzheimer's disease , entorhinal cortex , audiology , disease , white matter , frontotemporal dementia , pathology , medicine , cognition , magnetic resonance imaging , hippocampus , epilepsy , radiology
involvement of left anteromedial temporal lobe, medial prefrontal cortex, inferior longitudinal fasciculus, uncinate fasciculus and forceps minor, were observed in the PiB-negative group.Conclusions:Alzheimer’s disease pathology accounts for a high proportion of patients presenting with anomia, difficulty repeating sentences and phonological errors. Highly asymmetric MRI findings and preserved spatial perceptual skills, suggest that AD pathology is absent. In such instances, a progranulin gene mutation should be suspected.