Premium
F3‐03‐02: COGNITIVE EFFECTS OF TBI IN OLDER VETERANS
Author(s) -
Peltz Carrie,
Kramer Joel,
Kenney Kimbra,
Yaffe Kristine,
DiazArrastia Ramon
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.258
Subject(s) - traumatic brain injury , medicine , neuropsychology , dementia , head injury , cognition , psychiatry , clinical psychology , physical therapy , disease
NTT patients (p<.001). TBI was significantly associated with increased dementia risk (hazard ratio/95% confidence-interval (HR/CI): 1.46/1.41-1.52) even after adjusting formultiple dementia predictors and trauma severity score (HR/CI: 1.26/1.21-1.31). Stratification by TBI severity suggested a doseresponse that was further elucidated by age-stratification. An interaction between age category and TBI severity was found (p<.0001) such that moderate/severe TBI was associated with increased dementia risk across all ages, with highest risk in adults age 55-64 (HR/CI: 1.69/1.38-2.07), while mild TBI became a relatively more important dementia predictor with increasing age (age 55-64 HR/CI: 1.10/.79-1.52 vs. age 65-74 HR/CI: 1.26/1.05-1.52). Conclusions:Moderate/severe TBI sustained at age 55 or any TBI sustained at age 65 may represent significant risk factors for dementia over the subsequent 5-6 years. Adults under age 65may bemore resilient to, or take longer to manifest, the effects of mild TBI than adults over age 65.