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F3‐01‐04: SOCIOECONOMIC STATUS AND CHOLESTEROL LEVELS IN MIDLIFE AND RISK OF DEMENTIA 35 YEARS LATER
Author(s) -
Beeri Michal Schnaider,
RavonaSpringer Ramit,
Goldbourt Uri
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.251
Subject(s) - dementia , socioeconomic status , medicine , gerontology , demography , incidence (geometry) , logistic regression , longitudinal study , risk factor , vascular dementia , psychology , disease , population , environmental health , sociology , physics , pathology , optics
in fifth quintile a 64% increased risk of AD (fully adjusted Hazard Ratio {aHR} 1.64, 95% Confidence Interval {CI} 1.1, 2.4). For DBP a 58% increased risk (aHR for fifth quintile versus first quintile 1⁄4 1.58, 95% CI 1.1, 2.3). There was suggestion of a curvilinear association between DBP and AD; compared to those in the third quintile, those in the first quintile 18% increased risk and those in the fifth 85% (HR1⁄4 1.18, 95% CI 1.1, 2.5, and HR1⁄41.85, 95% CI 1.3, 2.6,). Change in SBP was not associated with risk of AD. Change in DBP increased risk of AD, compared to those who increased 0-5mmHg, those who decreased 15mmHg or more a 60% increased risk (aHR 1.60, 95% CI 1.1,2.5) and those who increased 15mmHg or more a 41% increased risk (aHR 1.41, 95% CI 1.2, 3.4). Conclusions: Elevated diastolic and systolic blood pressure in young adulthood and large changes in diastolic blood pressure in midlife are associated with increased risk of Alzheimer’s disease. Modification of vascular risk factors for potential prevention should begin early in the lifecourse.