Premium
O2‐14‐06: ABNORMALITIES OF FIXATION, SACCADE, AND PURSUIT IN POSTERIOR CORTICAL ATROPHY COMPARED TO TYPICAL AD
Author(s) -
Shakespeare Tim,
Yong Keir,
Kaski Diego,
Schott Jonathan M.,
Crutch Sebastian
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.239
Subject(s) - saccade , audiology , eye movement , fixation (population genetics) , smooth pursuit , saccadic masking , atrophy , posterior cortical atrophy , psychology , medicine , apraxia , ophthalmology , neuroscience , disease , dementia , population , environmental health , aphasia
Background: Patients with the neurodegenerative syndrome posterior cortical atrophy (PCA), have impairments in visuo-perceptual and visuo-spatial processing, spelling and calculation, associated with atrophy of the parietal and occipital lobes. Patients often have oculomotor apraxia however the proportion of patients with this symptom varies widely across studies. Our primary interest was to undertake a detailed assessment of oculomotor function in patients with PCA to explore the extent to which high-order visual processing deficits relate to lower-order oculomotor impairment. Methods: Fixation, saccade and smooth pursuit were assessed in 20 PCA, 12 AD and 22 healthy controls. Stimuli were presented on a Dell Inspiron One desktop computer from a fixed viewing