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O2‐07‐05: DIFFERENCES IN SPATIAL AND TEMPORAL ORDER MEMORY IN VARIOUS NEURODEGENERATIVE DEMENTIAS
Author(s) -
Laczó Jan,
Cerman Jiri,
Andel Ross,
Gazova Ivana,
Vlcek Kamil,
Vyhnalek Martin,
Mokrisova Ivana,
Hyncicova Eva,
Lerch Ondrej,
Parizkova Martina,
Sheardova Katerina,
Hort Jakub
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.196
Subject(s) - episodic memory , psychology , audiology , boston naming test , frontotemporal lobar degeneration , temporal lobe , dementia , dementia with lewy bodies , frontotemporal dementia , spatial memory , recall , neuropsychology , cognition , neuroscience , cognitive psychology , medicine , disease , working memory , pathology , epilepsy
memory (MOD-MEM) included 43% of patients. On visual inspection these patients had more severe MTA and were more often APOE e4 positive. Memory-spared clusters mild-executive (MILD-EXE), mild-visuoperception-language (MILD-VILA) and moderate-visuospatial (MOD-VISP) included 30% of patients. Using MILD-MEM as reference cluster, younger age was associated with higher likelihood for membership of MOD-VISP (Odds Ratio [OR] 6.21, 95% confidence interval [CI] 3.56-10.83) and MILD-EXE (OR 2.06, CI 1.32-3.23). Membership of MOD-VISP was more likely when APOE e4 was absent (OR 1.82, CI 1.04-3.20) and PA and GCAwere more severe (resp. OR 2.17, CI 1.15-4.10 and OR 2.64, CI 1.44-4.84). On visual inspection, MTA was less severe in memory-spared clusters than in other clusters. Finally, mild-diffuse (MILD-DIFF), moderate-language (MOD-LAN) and severe-diffuse (SEV-DIFF) were characterized by a memory-indifferent profile and included 28% of patients. Using MILD-MEM as reference, membership of SEV-DIFF was more likely when patients were younger (OR 2.77, CI 1.65-4.63), had longer duration of complaints (OR 2.18, CI 1.04-4.57) and had more severe PA and GCA (resp. OR 2.10, CI 1.07-3.76 and OR 2.28, CI 1.29-4.03). Conclusions: We demonstrated that LCA is an eligible method to identify cognitive subtypes in AD dementia using an extensive neuropsychological test battery. The cluster characteristics we found corresponded with earlier findings regarding the association between neurobiological characteristics and cognition.