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O2‐02‐02: PHYSICAL ACTIVITY AS A PREDICTOR OF CLINICAL COURSE IN MILD AD: THE DANISH ALZHEIMER'S INTERVENTION STUDY (DAISY)
Author(s) -
Frederiksen Kristian Steen,
Waldorff Frans Boch,
Waldemar Gunhild
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.162
Subject(s) - apathy , quality of life (healthcare) , activities of daily living , anxiety , cognition , medicine , disease , alzheimer's disease , physical therapy , psychology , psychiatry , nursing
fracture in Copenhagen Hospital region. Patients were identified using the national indicator project database for hip fracture. Data about medication use during hospitalization was acquired from the electronic medication system. Data were linked with information from nationwide registers, which allowed retrieval of information about dementia, comorbidity and prior drug use. The study population consisted of 1535 persons, among which 303 (19.8%) suffered from dementia. Patients with dementia were older (85.5 years vs. 82.8 years, p<0.0001), more likely to reside in nursing homes (43.1% vs. 10.4%, p<0.0001) and had higher ASA scores. Majority (89.4-91.4%) of patients with and without dementia received paracetamol as a standing order. During the first post-operative day 71.3% of patients with and without dementia received morphine. However, patients with dementia received lower dosages (36.3mg 6 22.2mg vs. 42.6mg 6 28.5mg, p1⁄40.0087). At day two patients with dementia also received slightly lower dosages (34.4mg6 25.0mg vs. 37.2mg6 27.0mg), but there was no difference on day three. We did not find any major differences between patients with and without dementia in the post-operative pain treatment day 1-3 after hip fracture; however pain treatment after day 3 was not assessed. A similar percentage of patients with and without dementia received paracetamol and morphine as part of the post-operative pain treatment. Patients with dementia received slightly lower dosages, which was most pronounced during the first day. This may be appropriate as patients with dementia in this population were older and may not tolerate opioids as well as elderly without cognitive impairment.