Premium
S2‐02‐02: PHAGOCYTOSIS PATHWAY OF MICROGLIA LINKED TO NEURODEGENERATION
Author(s) -
LinnartzGerlach Bettina,
Neumann Harald,
Bodea Liviu,
Claude Janine
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.134
Subject(s) - microglia , neurodegeneration , trem2 , siglec , immunoglobulin superfamily , receptor , biology , microbiology and biotechnology , innate immune system , opsonin , phagocytosis , complement receptor , neuroinflammation , neuroscience , immune system , immunology , inflammation , complement system , biochemistry , medicine , disease , pathology
not available. S2-02-04 MECHANISMS OF TAUHAPLOTYPE EFFECTS ON DISEASE Richard Wade-Martins, Oxford Parkinson’s Disease Centre, Oxford, United Kingdom. Contact e-mail: richard.wade-martins@dpag.ox.ac.uk Abstract not available. MONDAY, JULY 14, 2014 FEATURED RESEARCH SESSIONS: F2-01 COGNITION-FOCUSED INTERVENTIONS FOR PERSONS WITH MILD DEMENTIA AND MCI: CHALLENGES AND NEW DIRECTIONSnot available. MONDAY, JULY 14, 2014 FEATURED RESEARCH SESSIONS: F2-01 COGNITION-FOCUSED INTERVENTIONS FOR PERSONS WITH MILD DEMENTIA AND MCI: CHALLENGES AND NEW DIRECTIONS F2-01-01 COGNITIVE TRAINING FOR OLDER ADULTS WITHMCI ANDMILDDEMENTIA: STATEOF THE SCIENCE, CENTRAL CHALLENGES, AND POSSIBLE SOLUTIONS Alex Bahar-Fuchs, Benjamin M. Hampstead, Linda Clare, The Australian National University, Canberra, Australia; Emory University, Atlanta, Georgia, United States; Bangor University, Bangor, United Kingdom. Contact e-mail: alex.baharfuchs@anu.edu.au Background: Research on the effects of cognitive training (CT) on older adults has gained much popularity in recent years across the spectrum from healthy ageing to persons with mild-to-moderate dementia. Whether CT should be clinically recommended for older adults with dementia or for those with MCI has, however, been difficult to establish due to inconclusive evidence. We conducted a meta-review of the literature published in recent years in an attempt to identify factors contributing to central methodological challenges in this area. Methods: Sixteen reviews of the literature on the effects of CT for persons with MCI or mild-moderate dementia, published between 1992 and 2013 were reviewed in terms of their type, inclusion criteria, conclusions, and key recommendations. Key challenges for research in this field were extracted from these reviews. Results: Reviews varied in type, methods, findings and conclusions, but overall tended to favor the potential of CT interventions for individuals with MCI, and to a lesser extent for individuals with mild dementia. Several theoretical, methodological, and practical issues cloud research in this field and slow progress in this area. These include: Inconsistent terminology with which to refer to different cognition-focused interventions; Heterogeneity in interventions in relation to the targeted cognitive domains (e.g., memory, attention, executive function), and the use of specific techniques and combination of techniques (compensatory vs. restorative, rehearsal-based vs. semantic elaboration); Inconsistency in the choice and classification of relevant outcomes and their measures; Rationale for determining intervention dose; Sample size and power issues; Participant selection issues; Choice and design of appropriate control conditions; Insufficient understanding of treatment response variables e.g., personality, mood, biomarker status, awareness of deficits, etc; Low methodological quality leading to many studies being excluded from systematic reviews (e.g., non RCT, mixed interventions). Conclusions: Key issues that slow progress in this field have been identified and a number of suggested solutions will be discussed. Greater collaboration between clinical researchers in the field of dementia risk reduction including CT and researchers specializing in the design of behavior-change interventions is likely to lead to an increased quality of interventions in this field. An international interest group focusing on the development of greater consensus and minimum intervention standards is recommended. F2-01-02 A COMPARATIVE STUDY OF MNEMONIC STRATEGYAND SPACED RETRIEVALTRAINING IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT Benjamin M. Hampstead, Anthony Y. Stringer, Krish Sathian, Emory University, Atlanta, Georgia, United States. Contact e-mail: bhampst@emory. edu Background: We previously reported that mnemonic strategy training (MST) improved memory for object-location associations more than repeated stimulus exposure in patients with mild cognitive impairment (MCI) (Neuropsychology, 26(3), 385-399). These behavioral differences were accompanied by activation increases in prefrontal, parietal, and medial temporal cortical regions, as measured using functional magnetic resonance imaging (fMRI). In the current single-blind, randomized controlled trial, we