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O1‐12‐02: AMYLOID BURDEN, CORTICAL THICKNESS, AND COGNITIVE FUNCTION IN THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION
Author(s) -
Doherty Benjamin Matthew,
Oh Jennifer M.,
Schultz Stephanie A.,
Koscik Rebecca L.,
Dowling N. Maritza,
Barnhart Todd E.,
Murali Dhanabalan,
Gallagher Catherine L.,
Carlsson Cynthia M.,
Bendlin Barbara B.,
LaRue Asenath,
Hermann Bruce P.,
Rowley Howard A.,
Asthana Sanjay,
Sager Mark A.,
Christian Brad T.,
Johnson Sterling C.,
Okonkwo Ozioma C.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.123
Subject(s) - cognition , pittsburgh compound b , clinical dementia rating , cognitive decline , entorhinal cortex , psychology , audiology , effects of sleep deprivation on cognitive performance , cognitive test , dementia , medicine , neuroscience , disease , hippocampus , cognitive impairment
There is a growing interest in understanding how amyloid-β (Aβ) accumulation in preclinical Alzheimer's disease relates to brain morphometric measures and cognition. Existing investigations in this area have been primarily conducted in older cognitively-normal (CN) individuals. Therefore, not much is known about the associations between Aβ burden, cortical thickness, and cognition in midlife. We examined this question in 109, CN, late-middle-aged adults (mean age=60.72±5.65 years) from the Wisconsin Registry for Alzheimer's Prevention. They underwent Pittsburgh Compound B (PiB) and anatomical magnetic resonance (MR) imaging, and a comprehensive cognitive exam. Blinded visual rating of the PiB scans was used to classify the participants as Aβ+ or Aβ-. Cortical thickness measurements were derived from the MR images. The Aβ+ group exhibited significant thinning of the entorhinal cortex and accelerated age-associated thinning of the parahippocampal gyrus compared with the Aβ- group. The Aβ+ group also had numerically lower, but nonsignificant, test scores on all cognitive measures, and significantly faster age-associated cognitive decline on measures of Speed & Flexibility, Verbal Ability, and Visuospatial Ability. Our findings suggest that early Aβ aggregation is associated with deleterious changes in brain structure and cognitive function, even in midlife, and that the temporal lag between Aβ deposition and the inception of neurodegenerative/cognitive changes might be narrower than currently thought.