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O1‐11‐05: MORTALITY IN DEMENTIA: DATA FROM SVEDEM, SWEDISH DEMENTIA REGISTRY
Author(s) -
GarciaPtacek Sara,
Farahmand Bahman,
Kåreholt Ingemar,
Religa Dorota,
Cuadrado Maria Luz,
Eriksdotter Maria
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.120
Subject(s) - dementia , hazard ratio , medicine , vascular dementia , lewy body , confidence interval , gerontology , pediatrics , disease
individuals , who had a single clinical neurodegenerative disease diagnosis of the following: Probable AD(ProbAD, N1⁄48,798), Possible AD(PossAD, N1⁄41,680), VaD(N1⁄4213), dementia with Lewy bodies(DLB, N1⁄4476), frontotemporal dementia(FTD, N1⁄4642), Parkinson’s disease(PD, N1⁄4485), progressive supranuclear palsy(N1⁄480), corticobasal degeneration(N1⁄4126), or prion disease(N1⁄478) comparing these to cognitively normal individuals(normals, N1⁄48,384). The presence/absence of the followingwas compared: heart attack, atrial fibrillation, stroke, congestive heart failure, hypertension, hyperlipidemia, diabetes and bodymass indexes(BMI). Generalized linearmixedmodels were used having age at visit, gender,BMI, cardiovascular disease and risk factors as fixed effects and coordinating centers as random effects. Each neurodegenerative disease was ran separately as an output variable having normal as a reference group.Results: ProbAD, PossAD, and DLB had significantly lower BMIs when compared to normals (p values < 0.03). VaD had greater frequencies of hypertension, diabetes, atrial fibrillation, and stroke (p values <0.04). ProbAD had lower frequencies of atrial fibrillation compared to normals (p value <0.001), while PossAD had greater frequencies of stroke (p value <0.001). Individuals with PD had a lower frequency of stroke (p1⁄40.047). Therewere no differences between normals andPSP,CBDor prion disease. BMIwasmain factor contributing to nearly all cardiovascular disease and risk factors.Conclusions: These data demonstrate that the frequencies of cardiovascular risk factors differ across neurodegenerative diseases, supporting the idea that certain molecular mechanisms may be related to neurodegenerative disease types. The main difference in this study was BMI, indicating that perhaps many differences found with respect to cardiovascular disease and risk factors may be driven by BMI.