Premium
O1‐09‐02: DETECTION AND QUANTIFICATION OF THE TAU PROTEIN AND ITS ISOFORMS IN THE CSF OF ALZHEIMER'S DISEASE PATIENTS USING MASS SPECTROMETRY
Author(s) -
Barthelemy Nicolas,
Lehmann Sylvain,
Hirtz Christophe,
Gabelle Audrey,
Sergeant Nicolas,
Fenaille François,
Vialaret Jérôme,
Schraen Susanna,
Bros Pauline,
Tiers Laurent,
Delaby Constance,
Junot Christophe,
Touchon Jacques,
Buee Luc,
Becher François
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.105
Subject(s) - gene isoform , biomarker , tau protein , alzheimer's disease , mass spectrometry , computational biology , dementia , disease , chemistry , cerebrospinal fluid , immunoprecipitation , biology , medicine , biochemistry , pathology , neuroscience , chromatography , gene
addition, the results show a statistically significant improvement in clinician confidence for their diagnosis. In comparison with BNA data, patients were younger and more frequently diagnosed with AD. Conclusions: Clinicians tend to heavily rely on the CSF AD biomarkers results and are more confident in their diagnoses using CSF AD biomarkers. Thus, these biomarkers appear as a key tool in clinical practice.