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O1‐07‐06: COMPARISON OF 18F‐FLUTEMETAMOL UPTAKE AND CSF MEASUREMENTS IN COGNITIVELY INTACT OLDER INDIVIDUALS
Author(s) -
Schaeverbeke Jolien,
Adamczuk Katarzyna,
Bruffaerts Rose,
Nelissen Natalie,
Neyens Veerle,
Dupont Patrick,
Laere Koen,
Poesen Koen,
Vandenberghe Rik R.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.097
Subject(s) - nuclear medicine , medicine , cerebrospinal fluid , pathology , psychology
between Wave1 and Wave2. Results: Individuals with greater Ab burden had lower CVR at both Wave1 and Wave2, with the effect being most pronounced in the occipital lobe (Fig.1). The reduced CVRmay be attributed to Ab-induced angiopathy. CBF at Wave1 did not show a significant relationship with Ab deposition (Fig.2a). However, Wave2 CBF showed a positive correlation (p1⁄40.01) with Wave1 Ab burden (Fig.2b). Analysis of CBF change revealed that individuals with greater Ab burden tended to show an increase in CBF over the four-year interval (p1⁄40.009, Fig.2c). The increased CBF might be due to compensatory processes, as more neuronal processing might be needed to achieve the same computational power when neural efficiency is dampened by Ab-induced neurotoxicity. Conclusions: Ab burden appears to have a negative impact on cerebral vascular parameters. Greater Ab burden reduces the vessel’s ability to dilate. The impact of Ab on CBF may be a slower process. But over time, individuals with high Ab show elevated CBF, suggesting that more neural resources are needed to maintain the same brain function.