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O1‐07‐03: EFFECTS OF AMYLOID STATUS AND AGE ON LONGITUDINAL REGIONAL BRAIN ATROPHY IN ELDERLY HEALTHY CONTROLS
Author(s) -
Nosheny Rachel L.,
Insel Philip,
Mattsson Niklas,
Tosun Duygu,
Truran Diana,
Schuff Norbert,
Jagust William,
Petersen Ronald Carl,
Jack Clifford,
Aisen Paul,
Weiner Michael
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.094
Subject(s) - atrophy , parahippocampal gyrus , entorhinal cortex , temporal lobe , brain size , psychology , gyrus , inferior temporal gyrus , superior temporal gyrus , population , supramarginal gyrus , neuroscience , medicine , hippocampus , magnetic resonance imaging , epilepsy , radiology , functional magnetic resonance imaging , environmental health
T1 image,allowing assessment of volume, mean diffusivity (MD) and fractional anisotropy (FA) in these regions. Longitudinal DT images were coregistered using tensor-based registration to examine FA, MD, axial and radial diffusivity (AD and RD) in the cingulum and fornix (ICBM-DTI81 atlas). Whole brain and ventricular volumes were segmented using semi-automated techniques and atrophy/expansion rates calculated using the boundary shift integral. Linear regression, adjusting for age and gender, was used to assess differences in the imaging measures and their mean rates of change between MC and non-carrier groups. Results: The cohort comprised 12 mutation-negative participants and 17 MCs, six of whom reported symptoms at follow-up.MCs were on average 6.7 years younger than their parental age at symptom onset. MCs had smaller thalamic volumes bilaterally at baseline and follow-up, but there was little evidence for a difference in the rate of change over this interval. There was weak evidence for higher FA in bilateral thalamus and decreased AD in right cingulum at baseline and follow-up and lower right thalamic MD at baseline in MCs. When examined separately, MCs who became symptomatic had higher thalamic FA at follow-up thanMCs who remained asymptomatic but bothMC groups had smaller thalamic volumes than non-carriers. No significant group differences were evident for other imaging measures. Conclusions: Lower thalamic volumes and altered diffusivity were evident in FAD MCs compared to non-carriers at a stage when whole brain volumes and atrophy rates were similar. Thalamic FA in particular merits further investigation as a marker of early disease progression in larger FAD cohorts.