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O1‐05‐03: CONSORTIA DRIVEN APPROACH TO ADDRESSING CLINICAL MEANINGFULNESS IN EARLY AD
Author(s) -
Ropacki Michael T.,
Hannesdottir Kristin,
Hendrix Suzanne,
Gordon Mark F.,
Stephenson Diane,
Coons Stephen J.,
Stern Robert A.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.082
Subject(s) - concordance , leverage (statistics) , dementia , clinical trial , psychology , cognition , population , narrative , disease , medicine , applied psychology , computer science , artificial intelligence , pathology , psychiatry , linguistics , philosophy , environmental health
short-term worsening and 50 showed short-term improvement (mean time to first change1⁄4 170 days 6 std 108 days). Of the 73 patients with standardized cognitive tests scores , 25 showed short-term worsening (34%) and 48 showed short-term improvement, (mean time to first change1⁄4 106 days (6 std 92 days). F irst change scores were significantly correlated. In all measurements, short-term improvements led to significant increases in the probability of worsening (p<0.01). In all measures, short-term worsening to any degree was associated with long-term worsening. Initial improvement results were similar -e.g. initial symptomatic improvement resulted in 90% still improved at 1 year, and 67% at 2 years. In contrast to worsening, the greater the degree of improvement, the higher the chance of remaining improved. Conclusions: Regarding treatment with cholinesterase inhibitors, clinically important improvement early in the course of treatment forecasted longer term improvement, especially when improvements were large. Any degree of worsening was associated with persistently poor long-term outcomes. The twoyear time course suggests that this might extend to potentially diseasemodifying compounds.