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IC‐01‐05: REGIONAL CEREBRAL BLOOD FLOW PATTERN ASSOCIATED WITH SUBCLINICAL COGNITIVE DECLINE AND VASCULAR RISK FACTORS IN HEALTHY, MIDDLE‐AGED MALES
Author(s) -
Henriksen Otto Mølby,
Hansen Naja Liv L.,
Mortensen Erik L.,
Hallam Dorte M.,
Osler Merete,
Rostrup Egill
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.04.022
Subject(s) - cerebral blood flow , cognitive decline , cardiology , cognition , medicine , hyperintensity , subclinical infection , white matter , dementia , psychology , magnetic resonance imaging , disease , radiology , psychiatry
reference region. Quantitative MRI 3 measured the volumes of cerebral gray matter, hippocampi, and white matter hyperintensities (WMH) on MRI scans obtained nearest to PiB PET.Mixed effects regressionmodels of individual trajectories of memory and executive functioning were estimatedwith random effects of baseline level and rate of change. Demographic variables, baseline clinical diagnosis, global amyloid burden defined as the average DVR from cortical regions associated with Alzheimer’s amyloid pathology 1, MRI variables, and vascular risk factor burden defined as the simple sum of vascular risk factors present were entered into the model as fixed effects in a stepwise fashion. All fixed effects whose association withmemory or executive function passed a p-value threshold of 0.01 were carried forward to subsequent models. Results: In the first model, baseline diagnosiswas significantly associated with bothbaseline level and rate of change inmemory andexecutive function.Global amyloid burden, when added to this model, was significantly associated with baseline level and rate of change in one or both cognitive domains. When MRI measures were further added to the model, only hippocampus volume was a significant predictor of baseline level and rate of change in cognitive domains.When total vascular risk factor burdenwas further added to themodel, it significantly predicted baseline level of executive function.When total vascular risk factor burden was replaced with individual risks factors, only hyperlipidemia was significantly associated with baseline level of memory performance (Table). Conclusions: In a cohort of community based, predominantly nondemented individuals, greater vascular risk factor exposure was significantly associatedwith baseline level of executive function in amodel that included amyloid burden andMRImeasures of vascular and neurodegenerative disease.We conclude that modifiable vascular risk factors are important to cognitive health even after adjusting for the concurrent effects of cerebral amyloid burden.1. Marchant NL, Reed BR, DeCarli CS, et al. Cerebrovascular disease, beta-amyloid, and cognition in aging. Neurobiol Aging 2012;33:1006 e1025-1036.2. Marchant NL, Reed BR, Sanossian N, et al. The Aging Brain and Cognition: Contribution of Vascular Injury and Abeta to Mild Cognitive Dysfunction. JAMA neurology 2013:1-8.3. DeCarli C, Reed BR, Jagust W, Martinez O, Ortega M, Mungas D. Brain behavior relationships among African Americans, white, and Hispanics. Alzheimer Dis Assoc Disord 2008;22:382-391.