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P4‐255: Developing a National Institutional Review Board for Neurodegenerative Diseases
Author(s) -
Snyder Peter J.,
Carrillo Maria,
Knopman David S.,
Khachaturian Ara S.
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.285
Subject(s) - general partnership , institutional review board , political science , corporation , disease , public relations , business , medicine , public administration , pathology , law , psychiatry
with MWD50 was seen in women (P 1⁄4 0.02) but not men (P 1⁄4 0.97). In addition, MWD50 was associated with WBV in women (P 1⁄4 0.04) but not men (P 1⁄4 0.84). When WBV was added to the adjusted model predicting dementia, MWD50 was no longer significant (P 1⁄4 0.54) in the whole sample or in women (P 1⁄4 0.24). Conclusions: Exercise in mid-life reduces the risk for dementia in women independently of APOE-e4, hippocampal volume and the volume of white matter hyperintensities. This association is partially mediated by late-life brain volume, which is related to minutes of walking per day at age 50 in women, but not men. Estrogen in earlier adult and midlife may interact with exercise to upregulate BDNF, increasing brain reserve in late life (Eur J Neurosci 2001;14(12):1992-2002).