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P4–403: Serum 25‐hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly
Author(s) -
BrouwerBrolsma Elske,
Rest Ondine,
Tieland Michael,
Zwaluw Nikita,
Steegenga Wilma,
Adam Jos,
Loon Luc,
Feskens Edith,
Groot Lisette
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.236
Subject(s) - cognition , vitamin d and neurology , poisson regression , effects of sleep deprivation on cognitive performance , medicine , association (psychology) , cross sectional study , blood sampling , psychology , population , environmental health , psychiatry , pathology , psychotherapist
Background: The high prevalence of vitamin D deficiency in the elderly population is a commonly raised concern worldwide.With ageing as a joint risk factor for vitamin D deficiency and cognitive decline, together with many plausible biological mechanisms for a relationship between these two, we investigated the cross-sectional association between serum 25-hydroxyvitamin D (25(OH)D) and domain-specific cognitive performance in apparently healthy Dutch elderly, aged 65 years and older.Methods: Cognitive performance was assessed with an extensive test battery. Scores of the individual cognitive tests were clustered into compound scores for four neuropsychological domains: episodic memory (n1⁄42721), attention and working memory (n1⁄4787), information processing speed (n1⁄4798), and executive functioning (n1⁄4777). Multivariable regression analyses were used to investigate whether there was a linear association between serum 25(OH)D and domain-specific performance. The dose-response of the association was explored by analysing the associations per quartile of 25(OH)D status mean 25(OH)D level per quartile: 3069, 5065, 6765 and 94617 nmol/Land by Restricted Cubic Splines with three knots at 25(OH)D levels of 28, 58 and 94. Results: Participants were on average 72.5 (5.7) years of age and had a median MMSE score of 29 (25-75 percentile: 28-30). Multivariable linear regression analysis did not show a significant association between 25(OH)D and domain-specific cognitive performance after adjustment for potential confounders. Additional adjustment for depression or fasting plasma glucose levels did not alter these results. Multivariable linear regression analysis per 25(OH)D quartile did show significant associations between 25(OH)D and the cognitive domains ‘attention and working memory’ (b 0.01860.007, P1⁄40.009) and ‘information processing speed’ (b 0.01560.006, P1⁄40.01) among those with the lowest 25(OH)D levels. Restricted Cubic Splines confirmed this possible dose-response association between 25(OH)D and domain-specific cognitive performance, with a threshold level at a 25(OH)D level of about 60-80 nmol/L (P non-linearity: ranging from 0.09 0.33). Conclusions: Serum 25(OH)D was not linearly associated with cognitive performance in Dutch elderly. Linear regression analysis per quartile of 25(OH)D and Restricted Cubic Splines, however, did suggest a possible dose-response association. Though, since tests for non linearity were not significant, these results should be interpreted with caution.