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P4–391: Visual delayed recall as a predictor of conversion to Alzheimer's disease in patients with amnestic mild cognitive impairment
Author(s) -
Tabuchi Hajime,
Konishi Mika,
Kato Motoichiro,
Mimura Masaru
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.224
Subject(s) - audiology , psychology , geriatric depression scale , wechsler adult intelligence scale , raven's progressive matrices , boston naming test , neuropsychology , verbal fluency test , stroop effect , wechsler memory scale , neuropsychological test , medicine , psychiatry , cognition , depressive symptoms
Background:Amyloid imaging studies have shown early and focal striatal deposition in preclinical PS1 and PS2 carriers among ADAD families. We investigated whether striatal amyloid burden was associated with performance on cognitive tests, includingmeasures putatively sensitive to striatal cognitive functions.Methods:We studied n1⁄411 cognitively normal (CN) ADAD family participants (age 22-44 years) and n1⁄43 with MCI (age 35-48). Participants included 8 PS-1 and 4 APP mutation-carriers, and 2 non-carriers. Participants completed PiB-PET imaging and standard neuropsychological tests, including measures of episodic memory, visuospatial construction, language, attention and executive functions. As well, participants completed a "striatal" cognitive battery including measures tapping 1) procedural learning (serial reaction time task of implicit learning; Rotary Pursuit task; mirror reading task); 2) risk-reward decision making (Iowa Gambling Task); and 3) psychomotor speed/dexterity (finger tapping; grooved pegboard). PiB-PET imaging data were acquired 50-70minutes after injection. Striatal PiB bindingwas computed as the SUVR (cerebellum reference) of a hand-drawn anterior-ventral striatum region of interest. Precuneus was a comparison ROI.Results: PiB SUVR in the anterior-ventral striatum ranged from 1.01 to 3.41 (mean 1.83; SD 0.78); in the precuneus PiB SUVR range from 1.26 to 3.31 (mean 1.76; SD 0.53). Age was correlatedwith striatal PiB (r1⁄4.67, p<.01) but not in the precuneus. AmongCN participants only, partial correlations (age-controlled) between striatal PiB and striatal cognitive measures were significant (p .05, two-tailed) for finger tapping (r1⁄4.65); mirror reading (r1⁄4.79) and Iowa Gambling Task (r1⁄4.74). Traditional neuropsychological tests also correlated with striatal PiB in CN participants, including MMSE, Boston Naming Test, Block Design and CERAD Word List Learning (partial r’s .63 to .78). In CN and MCI participants combined (n1⁄414), only finger tapping (non-dominant hand) and the IowaGambling Task were correlated with striatal PiB (see Figure). A similar pattern of correlations was observed between precuneus PiB SUVR and striatal cognitive measures, as well as with traditional neuropsychological measures. Corresponding analyses using pons as reference are underway and will be presented. Conclusions: Cognitive measures tapping behavioral functions of the striatum may be useful to explore in larger studies of preclinical AD.