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P4–389: Attenuation of practice effects on neuropsychological performance is a potential marker of preclinical Alzheimer's disease
Author(s) -
Ruvolo David,
Chasse Rachel,
Dreyfus Denise Maue,
Ver Elizabeth,
Grant Elizabeth,
Morris John,
Hassenstab Jason
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.222
Subject(s) - clinical dementia rating , dementia , cognition , neuropsychology , effects of sleep deprivation on cognitive performance , cognitive decline , cognitive test , medicine , psychology , disease , test (biology) , audiology , clinical psychology , clinical practice , psychiatry , family medicine , paleontology , biology
(p< .01), visual recall (p1⁄4.03), attention (p1⁄4.02), and set-shifting (p1⁄4.01). Using the Super-Normal group norms, Progressors reached a -1.5 SD decline in logical memory earlier than using the combined group norms. Across a range of SD cutoff scores, diagnostic sensitivity improved to amaximum of 84% true positive, but specificity remained unacceptably low and mostly decreased compared to the combined group norms.Conclusions: Including individuals with preclinical AD in normative samples increases variability and magnifies age effects. However, cognitive cutoff scores, even those derived from exceptionally robust norms, have poor specificity and should not be used to diagnose AD.