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P4–379: The comparison of cognitive profiles and gray matter densities between MCI and normal cognition in de novo PD
Author(s) -
Kim Sang Jin
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.212
Subject(s) - neuropsychology , precuneus , voxel based morphometry , medicine , psychology , dementia , verbal memory , posterior cingulate , audiology , cardiology , cognition , neuroscience , magnetic resonance imaging , radiology , disease , white matter
Background:Mild cognitive impairment (MCI) may occur in patients with newly diagnosed PD. Some Parkinson’s disease patients with MCI (PDMCI) develop dementia earlier. Early identification of PD-MCI might be a clue for early detection of patients with PD at risk for dementia. This study aimed to recognize characteristics of motor symptoms, neuropsychological profiles and gray matter densities in newly diagnosed PD patients with MCI compared to PD patients with normal cognition (PD-NC). Methods: This study included drug-naive, de novo patients with 22 PD-MCI and 24 PDNC. All subjects underwent an extended neuropsychological test (Seoul neuropsychological screening battery) and were evaluated motor symptoms by UPDRS III. Gray matter density was analyzed by using voxel-based morphometry. Motor symptoms, neuropsychological profiles and gray matter density were compared between PD-MCI and PD-NC. Results: There was no significant difference in motor symptoms between PD-MCI and PD-NC groups. But the neuropsychological profiles of verbal memory domains revealed significant difference in PD-MCI group compare with PD-NC group (p<0.05). Gray matter density in left supamarginal, left precuneus, left posterior cingulated and right inferior temporal gyrus were significantly lower in the PD-MCI group compared to PD-NC group (p<0.001).Conclusions:De novo patients with PD-MCI revealed cognitive impairment, in particularly verbal memory domains. On the other hand, gray matter densities were lower in left supamarginal, left precuneus, left posterior cingulated and right inferior temporal gyrus. These results are compatible with previous study that neuroanatomical substrates of verbal memory dysfunction in PD are posterior cortical areas and supports recent results showing that early progression to dementia in PD is associated with cognitive impairments in posterior cortical area.