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P4–374: Evolution of hippocampal atrophy and episodic memory impairment along the Alzheimer disease biological continuum through the AD‐CSF‐Index
Author(s) -
Gispert Juan,
Molinuevo Jose Luis,
Pujol Jesus,
Rami Lorena
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.207
Subject(s) - atrophy , episodic memory , hippocampal formation , alzheimer's disease , dementia , memory impairment , voxel , psychology , pathology , neuroscience , medicine , cardiology , audiology , disease , cognition , radiology
parahippocampal white matter, cingulum, and corpus callosum). Results: The amyloid positive and negative groups did not differ on demographic or neuropsychological variables. Therewere no significant volume or perfusion differences in any of the ROIs examined; however, amyloid positive subjects had lower FA in the caudal anterior cingulum (p1⁄40.003) compared to amyloid negative subjects. Partial correlations that controlled for age and APOE 4 status revealed inverse relationships between precuneus SUVr and visual memory (WMS Visual reproduction, immediate recall: r1⁄4-0.44, p1⁄40.02) and perfusion from the precuneus ROI (r1⁄4-0.44, p1⁄40.02).Conclusions: These findings suggest that white matter integrity measured by DTI, particularly in the caudal anterior cingulum, is sensitive to Ab burden in individuals who do not yet exhibit cognitive disturbances. In the absence of significant structural or perfusion differences, this finding suggests that DTI may be a more sensitive method to detect brain changes in preclinical AD.