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P4–346: Beta‐amyloid peptide in the plasma of individuals undergoing plasmapheresis: Effect of age and donation frequency
Author(s) -
Costa Montserrat,
Ortiz Ana Maria,
RosaBray Marylin,
Jorquera Juan Ignacio
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.180
Subject(s) - plasmapheresis , donation , albumin , medicine , immunology , endocrinology , antibody , economic growth , economics
the potential biomarkers of AD-related pathology were only identified in a single cohort. However, four candidate biomarkers (alpha-1-antitrypsin, alpha-2-macroglobulin, apolipoprotein E and complement C3) were discovered in five independent research cohorts in these 21 studies. Further our replication study using Somamers found 18 of the 94 previously reported candidates to associate with AD-related phenotypes (FDR q-value < 0.1). In addition, we examined how well the most widely replicated candidate markers can predict AD phenotypes in multivariate classification models and followed their stability over time. Conclusions: Overall, our findings demonstrate that few candidate biomarkers replicate acrossmultiple studies. Our own replication study identifies some of those previously reported markers, and suggests that AD pathology affects the blood proteome with some consistency. Finally, we report on the ability of a set of well replicated biomarkers to predict AD and on how their level change over time.