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P4–343: A naturally occurring human IgG specific for oligomeric and fibrillar beta‐amyloid: In vitro and in vivo studies
Author(s) -
Devudu Puligedda Rama,
Levites Yona,
O'Nuallain Brian,
Ondrejcak Tomas,
Cruz Pedro,
Ladd Thomas,
Rowan Michael,
Dessain Scott
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.177
Subject(s) - antibody , in vitro , microbiology and biotechnology , monoclonal antibody , epitope , amyloid (mycology) , immunoglobulin light chain , chemistry , genetically modified mouse , in vivo , biochemistry , biology , transgene , immunology , gene , inorganic chemistry
affinity of fibrinogen for Abeta and formed tighter Abeta-altered fibrin clots. In vitro fibrinolysis assays revealed that these Abeta-altered fibrin clots showed an even greater delay in fibrinolysis compared with control Abeta-altered fibrin clots. Furthermore, an AD mouse model with diet-induced HCC had more significant impairments in learning and memory as well as severe cerebral amyloid angiopathy (CAA) and parenchymal Abeta deposits in the olfactory bulb, cortex and hippocampus compared to control groups.Conclusions:Therefore, we propose that effect of HC/HCTL on the interaction betweenAbeta and fibrin(ogen) may be associated with CAA development and cognitive decline and could be risk factor for AD associated with vascular dysfunction.