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P4‐315: The protective effect of genistein against ER stress‐mediated neuronal degeneration in ApoE‐/‐ mice fed a high‐fat diet
Author(s) -
Kwon Young Hye,
YounJin Park,
Jeon Soo Kyoung
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.096
Subject(s) - endocrinology , medicine , neurodegeneration , apolipoprotein e , hyperphosphorylation , kinase , biology , chemistry , biochemistry , disease
43 MCI subjects with MMSE adjusted were selected (age; 75.5 + 3.2, education ; 4.8 + 4.0,MMSE ; 23.5 + 4.2). All subjects were performed detailed neuropsychological tests and brain magnetic resonance imaging. We rated the severity of ischemic changes in white matter quantitatively, which was divided to five areas in each hemisphere. Results: The Binswanger type VCIND subjects performed better than VaD subjects in all cognitive domains. The Binswanger type VCIND group showed higher performances than MCI group in memory domain but lower performances in Rey figure copying test and frontal-executive domains. The comparison of severity of white matter ischemic changes betweenBinswanger type VCIND andVaD showed no significant differences in their involved location and volumes.Conclusions:TheBinswanger type VCIND and VaD subjects showed marked neuropsychological differences, however, no differences in the severities of ischemic changes. We suggest the role of white matter ischemic abnormalities to cognition and possible pathophysiologic hypotheses. Reference: 1 Junque C, Pujol J, Vendrell P, et al. Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol 1990;47:151-156.