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P4‐298: The histidine analogue hydraide reduces BETA‐AMYLOID 42 levels and gamma‐secretase activity in a model of Alzheimer's disease
Author(s) -
Gwon ARyeong,
Jo DongGyu
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.079
Subject(s) - presenilin , pharmacology , neuroprotection , chemistry , nicastrin , histidine , biochemistry , senile plaques , lipid peroxidation , alzheimer's disease , medicine , oxidative stress , enzyme , disease
nol consumption is associated with pathological processing of APP in AD. To investigate the relationship between chronic alcohol consumption and Ab production, brain samples from rats fed an alcohol liquid diet for 5 weeks were analyzed. We show that the expression levels of APP, BACE1,and immature nicastrin were increased in the cerebellum, hippocampus,and striatum of the alcohol-fed group compared to the control group. Total nicastrin and PS1 levels were induced in the hippocampus of alcohol-fed rats. These data suggest that the altered expression of APP and Ab-producing enzymes possibly contributes to the chronic alcohol consumption-mediated pathogenesis of AD. Methods: Liquid diets Western blotting analysis Statistical analysisResults: Effects of chronic alcohol consumption on APP expression in various rat brain regions.Effects of chronic alcohol consumption on BACE expression in various rat brain regions.Effects of chronic alcohol consumption on PS1 expression in various rat brain regions.Effects of chronic alcohol consumption on nicastrin expression in various rat brain regions.Conclusions:we showed that the expression of APP and BACE1 was increased in the cerebellum, hippocampus, and striatum brain regions of the alcohol-fed group compared to the control diet group. PS1 expression and total nicastrin levels were slightly higher in the hippocampus. Immature nicastrin expression was higher in the cerebellum, hippocampus, and striatum brain regions of the alcohol-fed group compared to the control diet group. Mature nicastrin was detected more in the striatum of alcohol-fed rats. Brain region-specific changes in the expression of APP processing-related genes may be critical to developing alcohol-induced dementia and AD.