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P4‐268: A novel LXR beta‐selective partial agonist increases the ApoE‐ABCA1 pathway and decreases hippocampal BETA‐AMYLOID in cynomolgus monkeys without increasing liver triglycerides
Author(s) -
Bukhtiyarov Yuri,
Noto Paul,
Hardy Andy,
Meng Shi,
Kandpal Geeta,
Lipinski Kerry,
Howard Lamont,
Kruk Barbara,
Krosky Paula,
Guo Joan,
Guo Rong,
Gregg Richard,
Zhao Yi,
McGeehan Gerard,
Lala Deepak
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.049
Subject(s) - abca1 , apolipoprotein e , agonist , endocrinology , hippocampal formation , medicine , liver x receptor , amyloid beta , chemistry , cholesterol , neurodegeneration , pharmacology , biology , receptor , biochemistry , nuclear receptor , transporter , disease , transcription factor , gene
tive memory impairment with related worry or concern was also a strong predictor, but only among patients who had impaired IADL.Among the constructs examined in the Cache County Study, fMCI and pAD were relatively common, showed lowest rates of reversion to normality, andhadhighest predictive value for imminent dementia. Conclusions: These observations among cognitively impaired older individuals suggest that difficulty with instrumental abilities or related impairment in IADL is the strongest clinical predictor of near-term progression to dementia.