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DT‐01–04: Bimodal distribution of the brain beta‐amyloid load in the Alzheimer's disease cognitive continuum: Rate of regional accumulation or speed of spatial spread
Author(s) -
Tosun Duygu,
Weiner Michael
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.08.005
Subject(s) - amyloid (mycology) , standardized uptake value , cognition , neuroimaging , positron emission tomography , alzheimer's disease , psychology , medicine , neuroscience , pathology , disease
regions including the cuneus, middle frontal and middle temporal gyri, showed greater increases in rCBF in the FTO+ group. Individuals overweight in midlife showed a bilateral, symmetrical pattern of greater rCBF decline relative to thosewith normal weight in the superior and inferior frontal, post-central and inferior temporal gyri. Some brain regions including the posterior cingulate and precuneus showed greater increments in rCBF in the overweight group. Conclusions: FTO genotype and midlife adiposity are associated with distinct patterns of longitudinal rCBF changes in older adults. The brain regions involved include those vulnerable to Alzheimer’s pathology. These findingsmay represent early neural signatures of increased risk for AD and age-related memory impairment associated with midlife adiposity and FTO genotype.