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P2–285: Are the effects of age and education on neuropsychological performance the same in healthy individuals, individuals with mild cognitive impairment and those with Alzheimer's disease?
Author(s) -
Lubrini Genny,
Gozalbo Ana Simón,
Vincent Clarissa,
Acedo Carmen,
LópezArrieta Jesús,
Garcia Ana Frank
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.932
Subject(s) - neuropsychology , dementia , cognition , psychology , cognitive decline , effects of sleep deprivation on cognitive performance , observational study , disease , neuropsychological assessment , cognitive reserve , medicine , cognitive impairment , clinical psychology , gerontology , psychiatry
as a gold-standard examination towards dementia differential diagnosis. We aimed to investigate neuropsychological pattern so as to find different specific performances in the three nosological categories cited Methods: 170 (100 women) older adults were divided into MCI (67), DP (31) and AD (76). Mean age and educational level were, respectively, 73.5 (7.5) and 4.24 (3.8). One-way ANOVA, with Sidak post hoc, were used, and effect sizes were measured with "h" and Cohen’s "d" in the following tasks: Mini-Mental State Exam (for Global Cognition), Rey’s Auditory Verbal Learning Test (for Memory), Frontal Assessment Battery (for Executive Functions), Token Test (for Language), Lawton Scale (for Activities of Daily Living) and Geriatric Depression Scale (for depressive symptoms). S ignificance was established at the 0.05 level. Results: No differences in age and educational level was found, but the groups differed in Global Cognition (h 1⁄40.1) functional level (h 1⁄40.23), depressive symptoms (h 1⁄40.35), Executive Functions (h 1⁄40.18), Language (h 1⁄40.15), immediate (h 1⁄40.12) and delayed (h 1⁄40.12) recall and recognition (h 1⁄40.13) components of episodic memory. Post hoc analyses suggest that specific differences occurred (1) between MCI and AD: Global Cognition (d1⁄40.71), functional level (d1⁄41.22), depressive symptoms (d1⁄40.46), Executive Functions (d1⁄41.09), Language (d1⁄40.84), immediate recall (d1⁄40.47) and delayed recall (d1⁄40.43); (2) between DP and AD: Global Cognition (d1⁄40.66), functional level (d1⁄40.87), depressive symptoms (d1⁄41.45), Executive Functions (d1⁄40.70), Language (d1⁄40.88), immediate recall (d1⁄40.95), delayed recall (d1⁄40.97) and recognition (d1⁄41.12); (3) between MCI and DP: depressive symptoms (d1⁄42.01), immediate recall (d1⁄40.53), delayed recall (d1⁄40.56) and recognition (d1⁄40.78) from episodic memory. Conclusions: Our results show evidences of important contributions of the neuropsychological assessment to differential diagnosis between AD, DP and MCI. Special emphasis is given to measures of depressive symptoms, functional level and recognition from episodic memory.