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P2–224: Differential tau neuropathology within the nucleus of N. oculomotorius in Alzheimer's disease
Author(s) -
Scinto Leonard,
Geula Changiz
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.870
Subject(s) - pathology , somatic cell , biology , cytoplasm , immunohistochemistry , microbiology and biotechnology , neuroscience , medicine , genetics , gene
occurs at differing rates in organs and no studies to date have examined weights of peripheral organs in AD. Furthermore, many medical conditions are known to have certain associations with AD, and whether these associations may be due to decreases in weight and/or AD is unclear. Methods: The purpose of this study was to compare the last recorded body mass index (BMI) during life, autopsy weights of major organs including brain, heart, liver, lungs, kidney, and spleen, and commonly diagnosed medical conditions between clinicopathologically confirmed AD (N1⁄4 87), and non-demented individuals lacking a defined clinicopathological neurodegenerative disease (NC, N1⁄4 68). Multiple linear and logistic regression models adjusted for age at death, postmortem interval, gender, and last BMI were used. Results: BMI was significantly less in AD compared to NC at autopsy (23 vs.25), confirming previous reports. When examining individual organ weights, only the liver and brain in AD cases had significantly lower weights when compared to NC. There were no correlations between dementia duration or disease stage (Braak) and BMI to any organ weight. Furthermore, upon retrospective medical chart reviews of commonly diagnosed medical conditions in our database, AD cases had significantly lower incidences of arthritis (53 vs.75%), cataracts (39 vs.56%), gastroesophageal reflux disease (29 vs.47%), diverticular disease (22 vs.37%) renal (17 vs.43%), and congestive heart failure (15 vs.40%), but an increased incidence of incontinence (19 vs.55%) when compared to NC. Conclusions: The central nervous system is the integrating and command center of the body; sending and receiving information from all organs. These data further support AD can cause changes outside the realm of the central nervous system.