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P2–199: Choice of ADNI MPRAGE volume and RF coil affects brain segmentation comparability
Author(s) -
Brunton Simon,
Andrews Caroline,
Kempton Matthew,
Westman Eric,
Simmons Andrew
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.844
Subject(s) - white matter , segmentation , psychology , nuclear medicine , magnetic resonance imaging , medicine , computer science , artificial intelligence , radiology
Background: The ROSAS study is a monocentric observational study run in Toulouse, France, designed to identify AD biomarkers by collecting samples from Normal Controls (NC), Mild Cognitive Impairment (MCI) and AD subjects and following them over up to 4 years. Methods: 408 subjects of 65 years old or greater were enrolled in the study, including 110 NC (no memory complaints, MMSE 26 and CDR1⁄40), 100 MCI (MMSE 24 and CDR1⁄40.5, memory impairment based on Rey Auditory Verbal Learning Test and that did not meet DSM IV criteria for AD dementia) and 198 AD (12 MMSE 26 and CDR 0.5 and meeting DSM IV criteria). Subjects with other types of dementia and/or non-AD grounds for cognitive issues were not offered to participate. Clinical data, neuropsychological tests and biomarkers (blood, urine and CSF whenever possible) will be collected at Baseline and every 6 months until Month 48. MRI scans (3DT1, 3DT2, FLAIR, SWI, DWI and DTI) will be collected up to 3 times between Baseline and Month 48, using a Philips Achieva 3T scanner, for consenting subjects (n1⁄4158). The volume of intracranial cavity (ICV), left and right hippocampi (HCV), lateral ventricles (LVV) and whole brain (WBV) were assessed at Baseline using an automated multi-atlas segmentation algorithm. Descriptive statistics of