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P2–180: Segmentation analyses for assessing cortical SUVr in Alzheimer's disease using the novel PET amyloid tracer 18F‐NAV4694
Author(s) -
Seibyl John,
Barret Olivier,
Marek Kenneth,
Reininger Cornelia
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.825
Subject(s) - white matter , standardized uptake value , segmentation , voxel , nuclear medicine , grey matter , cerebellar cortex , positron emission tomography , medicine , magnetic resonance imaging , psychology , artificial intelligence , cerebellum , neuroscience , radiology , computer science
group differences were detected through two sample t-test. No significant difference was detected in ventral attention network between MCI and healthy elderly. While in dorsal attention network, significant difference was detected between MCI and healthy elderly. While taking comparison to healthy elderly, decreased functional connectivity to left IPL was observed in right cerebellar lobule VIIa Crus II, in addition to bilateral frontal cortex, right precuneus, right temporal cortex. And increased functional connectivity to left IPL was observed in right cerebellar vermis VI, right cerebellar lobule VI, right cerebellar VIIa Crus I, left cerebellar lobule VI, in additon to bilateral precuneus. Conclusions: TPJ and IPL is the core of ventral and dorsal attention network. Changes of functional activity were observed in dorsal attention network in MCI. And cerebellum may play an important role in this process.