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P2–167: Deep subcortical white‐matter hyperintensities independently predict depression in people with mild cognitive impairment
Author(s) -
Kim Doh Kwan,
Kim Sang Ha,
Choi Seong,
Lee Yujin,
Kim Seong Yoon,
Lee Jae Hong
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.812
Subject(s) - hyperintensity , depression (economics) , geriatric depression scale , dementia , medicine , neuropsychology , clinical dementia rating , cognitive impairment , psychology , psychiatry , cognition , physical therapy , magnetic resonance imaging , depressive symptoms , disease , radiology , economics , macroeconomics
Background: Presence of cerebral microbleeds indicates underlying vascular brain disease and has been implicated in lobar hemorrhages and dementia. All these conditions relate to shorter survival, but it remains unknown to what extent microbleeds increase the risk of mortality. We investigated the association of microbleeds with all-cause and cause-specific mortality in the general population.Methods:We rated the brainMRI scans of 3979 Rotterdam Scan Study participants to determine presence, number, and location of microbleeds. Cox proportional hazard models, adjusted for age, sex, subcohort, vascular risk factors, and other MRI markers of cerebral vascular disease, were applied to quantify the association of microbleeds with mortality. Results: After a mean follow up of 5.2 (6 1.1) years, 172 (4.3%) persons had died. Presence of microbleeds, and particularly deep or infratentorial microbleeds, was significantly associated with an increased risk of all-cause mortality (sex-, age-, subcohort adjusted hazard ratio (HR) 2.27; CI 1.503.45), independent of vascular risk factors (HR 1.87; 95% CI 1.202.92). The presence of deep or infratentorial microbleeds strongly associated with the risk of cardiovascular related mortality (HR 4.08; CI 1.789.39). Mortality risk increased with increasing number of microbleeds. Conclusions: The presence of microbleeds, particularly those in deep or infratentorial regions and multiple microbleeds indicates an increased risk of mortality. Our data suggest that microbleeds may mark severe underlying vascular pathology associated with poorer survival.