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P2–153: Reductions in white‐matter integrity in cognitively normal people with memory complaints
Author(s) -
Rhee Hak Young,
Park KeyChung
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.798
Subject(s) - precuneus , parahippocampal gyrus , audiology , cuneus , psychology , population , cognition , white matter , entorhinal cortex , medicine , psychiatry , hippocampus , temporal lobe , magnetic resonance imaging , neuroscience , radiology , environmental health , epilepsy
segmentation yielded very similar results compared to manual delineation. Atlas-based parcellation of mouse brains was checked on cresyl violet volumes and provided good results for 11 ROIs of the atlas. As expected, amyloid load displayed a great variability among structures and was high in the cerebral cortex, hippocampal region and olfactory bulbs (table). Conclusions: This work demonstrates the efficiency of our atlas-driven automated and non-user dependent method for the whole brain quantification of amyloid load in mouse models of AD. Such approach has the potential to accelerate amyloid load assessment in large scale studies and could be used for the preclinical evaluation of anti-amyloid drugs. Moreover, our methodological developments based on generic 3D histological imaging pave the way for future studies which could focus on a broad range of pathophysiological cellular and molecular biomarkers.