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P2–144: Age‐related frontal lobe compensation during novelty detection
Author(s) -
Chong Catherine,
Shi Jiong,
Sabbagh Marwan,
Chen Kewei,
Caselli Richard,
Baxter Leslie
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.788
Subject(s) - psychology , novelty , frontal lobe , audiology , episodic memory , recognition memory , recall , developmental psychology , neuroscience , cognitive psychology , cognition , medicine , social psychology
(p1⁄40.03), such that hippocampal volumewas associated with CDR progression only in low reserve subjects. Conclusions: Markers of amyloid and neurodegeneration may predict subsequent global functional impairment within CN subjects. Furthermore, the association between neurodegeneration and progression may be modified by both amyloid and cognitive reserve. Future analyses will examine relationships to objective measures of cognitive performance.