Premium
P2–099: Distribution of amyloid burden in PiB(+) subcortical vascular cognitive impairment compared with Alzheimer's disease
Author(s) -
Noh Young,
Seo Sang Won,
Kim JungHyun,
Lee JaeHong,
Jeon Seun,
Lee Jong,
Kim Geon Ha,
Cho Hanna,
Yoon Cindy,
Kim HeeJin,
Ye Byoung Seok,
Choe Yearn Seong,
Lee KyungHan,
Kim Jae Seung,
Na Duk L.
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.742
Subject(s) - pittsburgh compound b , statistical parametric mapping , precuneus , posterior cingulate , cardiology , cognitive impairment , dementia , psychology , medicine , striatum , pathological , amyloid (mycology) , cognition , neuroscience , pathology , disease , magnetic resonance imaging , radiology , dopamine
clustering linkage method was performed. Each identified subgroup of subjects was compared to an age and gender-matched control group by general linear model. Results:With cluster analysis, we classified AD patients into three, four, five and six anatomical subtypes according to the number of clusters. The three clusters were 1) medial temporal dominant (MT) subtype (n1⁄452) in which the bilateral medial temporal lobes were involved dominantly; 2) parietal dominant (P) subtype (n1⁄428) in which bilateral parietal, dorsolateral frontal areas were involved as well as precuneus, with relatively sparing medial temporal area; and 3) diffuse atrophy (D) subtype (n1⁄472) in which nearly all cortical areas were involved (figure). The neuropsychological results of these three subtypes were consistent with their pattern of cortical atrophy. Cluster analysis with four and five clusters showed that D subtype was further divided into two and three subtypes, respectively. Cluster analysis with six clusters further divided P subtype into left dominant and right dominant ones (figure). Conclusions: Our findings showed that AD patients can be divided into various subtypes according to cortical atrophy pattern, which is in line with their neuropsychological results. These findings are important as they confirm with imaging study that AD is not homogeneous.