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P2–086: MRS differentiates people with MCI who progress to dementia with Lewy bodies from people who progress to Alzheimer's disease
Author(s) -
Zhang Bing,
Ferman Tanis,
Boeve Bradley,
Smith Glenn E.,
MaroneySmith Mandie,
Knopman David,
Jack Clifford,
Petersen Ronald,
Kantarci Kejal
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.729
Subject(s) - dementia with lewy bodies , dementia , alzheimer's disease , medicine , posterior cingulate , psychology , cohort , memory clinic , pediatrics , disease , psychiatry , cognition
patients with and without apathy throughmeasurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FAvalues and the severity of apathy in AD patients with apathy.Results: The apathy group had significantly reduced FAvalues (p corrected<0.05) in the genu of the corpus callosum, compared to the nonapathy group. The severity of apathy was negatively correlated with FA values of the left anterior and posterior cingulum, right superior longitudinal fasciculus, splenium, body and genu of the corpus callosum and bilateral uncinate fasciculusin the apathy group (p corrected<0.05). Conclusions: This study was the first to explore FAvalues in whole brainWM inAD patients with apathy. The findings of thesemicrostructural alterations ofWMmay be the key to the understanding of underlying neurobiological mechanism and clinical significances of apathy in AD.