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P1–380: Circadian rhythms in cognitive functioning: Impact on signal detection in clinical trials of pro‐cognitive therapies
Author(s) -
Hufford Michael,
Davis Vicki,
Dgetluck Nancy,
Gawryl Maria,
Hilt Dana,
Rappaport Alon,
Keefe Richard
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.607
Subject(s) - neurocognitive , circadian rhythm , cognition , schizophrenia (object oriented programming) , psychology , clinical trial , placebo , cognitive test , neuropsychology , effects of sleep deprivation on cognitive performance , medicine , audiology , clinical psychology , psychiatry , neuroscience , alternative medicine , pathology
(p1⁄40.648). The 3 month difference of PSQI inMT group (-0.716 2.09) was significantly better than control group (1.13 6 1.73)(p1⁄40.011). Further adjusting by gender, age, education level and corresponding baseline measures, we found adjusted differences of MMSE, CASI, NPI and PSQI in MT group were slightly better than those in control group without statistical significance.Conclusions:AD patients usually had poor sleep quality. No apparently additional benefits of this MT were noted on these globally cognitive, neuropsychiatric and sleep quality assessments in AD for 3 months. Potentially, this MT might have promising effects on sleep quality and cognition in AD after 3 more months. It remains further investigation to understand the MT effect on cognition domains and other sleep dimensions in AD.