P1–372: Antidementia drugs are related to changes in gait: Which drugs for which walking condition?

classified as having MCI based on subjective memory complaints and scores less than 26/30 on theMontreal Cognitive Assessment but without a diagnosis of dementia or other neurodegenerative disease. Participants were randomized into one of three exercise groups: Resistance training, Aerobic training, or Balance and Tone (control). All groups completed two one-hour exercise sessions per week for a total of six months. Exercise classes were led by certified instructors, and were progressive in nature. We assessed associative memory using a face-place memory task, verbal learning and memory using the Rey Auditory Verbal Learning Test (RAVLT), and spatial memory using a computerized task which required participants to remember the location of dots presented on the screen.Results:After completion of the six month trial, the aerobic training group was able to remember significantly more items after interference on the RAVLT compared with the control group. In contrast, the resistance training group significantly improved their performance on the associative memory task. Additionally, both exercise groups demonstrated better spatial memory performance compared with the control group post-intervention however, this was only for remembering the spatial location of three items, which is the most difficult condition of the task. Conclusions: Taken together, our results provide support for the prevailing notion that exercise can positively impact cognitive functioning, although different types of exercise appear to exert their effects on distinct cognitive processes. Overall, physical activity represents an effective strategy to improve memory in those who have already begun to experience cognitive decline.