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P1–312: Phospholipid levels in multiple brain regions in Alzheimer's disease: A 3D 31P‐MRSI study
Author(s) -
Rijpma Anne,
Graaf Marinette,
Meulenbroek Olga,
Lansbergen Marieke,
Rikkert Marcel Olde,
Heerschap Arend
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.538
Subject(s) - phosphomonoesters , phosphocholine , magnetic resonance spectroscopic imaging , phospholipid , neuroscience , chemistry , hippocampus , neurodegeneration , temporal lobe , metabolite , phosphocreatine , nuclear magnetic resonance , medicine , magnetic resonance imaging , biology , biochemistry , disease , epilepsy , radiology , energy metabolism , physics , membrane , phosphatidylcholine
Card Sort Test, with the largest correlations observed between binding in the inferior parietal lobule and performance on Block Design (r 1⁄4 0.575, p 1⁄4 0.003). [11 C]PBR28 binding also inversely correlated with gray matter volume in the inferior parietal lobule, superior temporal cortex, middle and inferior temporal cortex, entorhinal cortex, posterior cingulate cortex, and precuneus (p < 0.05). Conclusions: Neuroinflammation, evidenced by increased [11 C]PBR28 binding to TSPO, occurs after conversion of MCI and worsens with AD progression. [11 C]PBR28 may be useful to predict conversion from MCI or to assess treatment response in AD.