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P1–292: Detectable levels of white matter PHF‐tau in Alzheimer's disease
Author(s) -
Hung Lin,
Watt Andrew,
Mulligan Rachel S.,
Furumoto Shozo,
FoderoTavoletti Michelle,
Chan Jacky,
Yanai Kazuhiko,
Masters Colin,
Kudo Yukitsuka,
Rowe Christopher,
Barnham Kevin,
Villemagne Victor
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.517
Subject(s) - grey matter , white matter , in vitro , chemistry , human brain , tau pathology , pathology , ligand (biochemistry) , alzheimer's disease , western blot , tau protein , biochemistry , receptor , disease , biology , medicine , neuroscience , magnetic resonance imaging , gene , radiology
(R1⁄4 0.84; P1⁄4 0.07) with P w S in the hippocampus. A moderate association in frontal cortex was also observed (R1⁄4 0.64). Conclusions: Our results suggest that water exchange processes at the CP may influence microvascular permeability, particularly in periventricular structures. If confirmed in a larger study, these findings would provide evidence for a role of the blood-cerebrospinal fluid barrier in the microvascular changes that accompany brain aging.