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P1–272: Reduced amyloid deposition and greater hypometabolism in people with Alzheimer's disease who are APOE‐ε4–positive
Author(s) -
Lehmann Manja,
Ghosh Pia,
Madison Cindee,
Karydas Anna,
Coppola Giovanni,
Miller Bruce,
Jagust William,
Rabinovici Gil
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.497
Subject(s) - apolipoprotein e , pittsburgh compound b , dementia , medicine , amyloid (mycology) , disease , pathophysiology , psychology , pathology , oncology , endocrinology
opportunities to characterize and evaluate AD. However, the correspondence between ADAD and the far more prevalent sporadic AD (sAD) requires elucidation. Methods: We analyzed functional connectivity in multiple brain networks in a cross-sectional cohort of ADAD (N1⁄487) and sAD (N1⁄4507) participants using resting state functional connectivity magnetic resonance imaging (rs-fcMRI). For both types of AD, we quantified rs-fcMRI changes in five resting state networks (RSNs) with respect to progressing clinical dementia rating (CDR) using general linear mixed models with factors CDR, AD type, and CDR€ı,’€ıVAD type interaction. In the ADAD group, we investigated rs-fcMRI changes with respect to years from expected onset of symptoms. We also related rs-fcMRI differences to genetic mutation type (presenilin 1, presenilin 2, amyloid precursor protein). Results: rs-fcMRI decreases with advancing clinical status were similar for both forms of AD in multiple RSNs. However, it is possible that ADAD causes more rapid loss with respect to CDR than sAD in certain RSNs. Within ADAD participants, functional connectivity in multiple RSNs was lower in individuals closer to their expected age of onset of symptoms. Within cognitively normal ADAD participants (N1⁄433), mutation-specific effects may occur in particular RSNs. Conclusions: rsfcMRI can elucidate specific AD subtypes and may help evaluate future therapeutic interventions.