Premium
P1–269: Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene‐dependent?
Author(s) -
Kinnunen Kirsi,
Ryan Natalie,
Cash David,
Leite António Bastos,
Finnegan Sarah,
Cardoso Manuel,
Leung Kelvin,
Modat Marc,
Benzinger Tammie,
Jack Clifford,
Marcus Daniel,
Raichle Marcus,
Thompson Paul,
Ringman John,
Ghetti Bernardino,
Salloway Stephen,
Sperling Reisa,
Schofield Peter,
Masters Colin,
Mayeux Richard,
Martins Ralph,
Weiner Michael,
Bateman Randall,
Goate Alison,
Fagan Anne,
Cairns Nigel,
Buckles Virginia,
Morris John,
Rossor Martin,
Ourselin Sebastien,
Fox Nick
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.494
Subject(s) - atrophy , putamen , presenilin , clinical dementia rating , cohort , dementia , hippocampus , asymptomatic carrier , medicine , thalamus , amyloid precursor protein , brain size , white matter , asymptomatic , pathology , oncology , neuroscience , alzheimer's disease , disease , psychology , magnetic resonance imaging , radiology
MCI patients, andmay lead to alterations in white matter integrity and blood flow that improve episodic memory performance. The improved memory performance and alterations in brain function in MCI patients were remarkable given their previous history and future probability of cognitive decline. Furthermore, these findings suggest the large-scale cerebrovascular and neurotrophic effects of exercise may reflect massive neuronal plasticity in MCI patients. Longitudinal clinical trials are required to determine whether moderate intensity walking exercise is effective in MCI to reduce or delay conversion to AD.