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P1–212: Detection of soluble oligomeric tau with morphology‐specific antibody fragments as a potential diagnostic method for Alzheimer's disease
Author(s) -
Tian Huilai,
Davidowitz Eliot,
Moe James,
Sierks Mike
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.436
Subject(s) - antibody , neurodegeneration , amyloid (mycology) , chemistry , microbiology and biotechnology , tau protein , biochemistry , alzheimer's disease , biology , medicine , disease , immunology , pathology , inorganic chemistry
Sequenom I-plex platform. CSF was obtained through lumbar puncture and analysed using multiplex xMAP Luminex platform. Statistical analyses were performed using mixed models, corrected for age, sex, APOE e 4 status and study site. Adjustment for multiple testing was set at a false discovery rate adjusted P 0.05). Conclusions: Our findings suggest that polymorphisms in the MS4A gene influence CSFA b 142 concentrations. This supports results from GWAS studies that this gene is a genetic risk factor for AD.