Premium
P1–194: A noninvasive device‐based approach to aid in the diagnosis of mTBI and Alzheimer's disease: Preliminary findings from Clinical Pilot Studies
Author(s) -
Simon Adam,
Ashrafiuon Hashem,
Ghorbanian Parham,
Devilbiss David
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.417
Subject(s) - concussion , electroencephalography , traumatic brain injury , medicine , disease , neuroimaging , cognition , physical medicine and rehabilitation , neuroscience , psychology , pathology , poison control , medical emergency , injury prevention , psychiatry
and might be due to increased vulnerability of their memory networks. Conclusions: The higher absolute power of upper alpha in resting EEG and the increased upper alpha desynchronization during cognitive task in non-demented older individuals carrying AD risk variant CLU CC implies unfavorable effect of this genotype on brain cholinergic pathways and hippocampus long before the presumable dementia. The results suggest that the neurophysiological markers may be important in monitoring disease progression in at-risk elderly.