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P1–188: CSF beta‐amyloid 42, CSF tau, hippocampal volume and verbal episodic memory performance in early versus late mild cognitive impairment
Author(s) -
Wolfsgruber Steffen,
Wagner Michael,
Jessen Frank,
Peters Oliver,
Wiltfang Jens,
Maier Wolfgang,
Kornhuber Johannes
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.411
Subject(s) - dementia , hippocampal formation , cognitive impairment , alzheimer's disease , abnormality , medicine , biomarker , neuroscience , disease , psychology , biology , psychiatry , biochemistry
agreement was 63%, 69%, and 69% for M/T, M/A, and A/T, respectively. In a subgroupwith CDR 1.0, agreement reached 87% (M/T). After exclusion of subjects with measures close to the cut-off values, agreement reached 79% (M/A) in the whole sample and 81% (M/A) in the group of patients with AD. Conclusions: The agreement found between the tested biomarkers of neuronal injury is overall insufficient to justify their potential interchangeability even in (mild) Alzheimer’s dementia in multi-center settings. A sub-study in the group of clearly AD-positive/negative subjects indicates that the lack of agreement is not mainly due to potential confounding factors such as cut-off values or methods of image data analysis. Prospective diagnostic criteria of AD should address relative importance of different markers of neuronal injury. Landau et al. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 2010;75:230-8. Jagust et al. Relationships between biomarkers in aging and dementia. Neurology. 2009;73:1193-9.